The Physiopathology of Cancer

This revised and enlarged edition of the original encyclopedic work on cancer is an important treatise consisting of 28 chapters by 32 contributors. The essayists are all leading cancer investigators, including one from the Chester Beatty Research Institute, London, England. The Physiopathology of Cancer is divided into four sections: (I) Biology, with chapters on (1) experimental cutaneous carcinoma, (2) pulmonary tumors in mice, (3) mammary tumors in mice, (4) tumors of the liver in rats, (5) genetics of neoplasia, (6) hormonal factors in experimental carcinogenesis, (7) virus induced tumors and the virus theory of cancer, (8) transplantable tumors, (9) heterologous transplantation, (10) leukemia, and (11) tissue culture in the study of malignancy; (II) Chemistry and Physics, including chapters on (12) nutrition and cancer, (13) chemical and genetic mechanisms of carcinogenesis-mode of action, (14) biological alkylating agents, (15) chemistry of cancer tissue, (16) nucleoproteins and cancer, (17) enzymes and cancer, (18) cancer cytochemistry and histochemistry, (19) experimental cancer chemotherapy, and (20) radiation and cancer; (III) Clinical Investigation with chapters on (21) natural history of neoplastic disease, (22) steroid hormone metabolism in cancer, (23) clinical investigation in cancer, (24) environmental cancer, and smoking and lung cancer, and (25) statistical studies in cancer; and (IV) Practical Applications with three final chapters on (26) clinical cancer chemotherapy, (27) applied exfoliative cytology, and (28) applied radiation therapy. This monumental work contains something of interest for investigators and clinicians dealing with practically every phase of cancer from the experimental to the clinical syndrome. Homburger's revised work presents a thorough cross-disciplinary analysis of cancer research and clinical observations. This book represents a truly great service to the whole field of cancer. Both the factual essays and the lengthy and complete bibliographical citations brilliantly codify the vast literature on this rapidly expanding subject. Every chapter deserves careful reading, for each provides well-documented evidence and wellthought-out perspectives. The book is rightfully dedicated to the late Dr. Francisco Duran-Reynals (1899-1958) whose life's work stands as an erect posture of scientific investigation on the cancer problem. JOSEPH THOMAS VELARDO